Beta3_LVH: towards a treatment against heart failure

Beta-adrenergic receptors are subdivided into three types: beta1-, beta2- and beta3-adrenergic receptors. Beta1-adrenergic receptors are predominant in the heart, beta2-adrenergic receptors--in the respiratory system, and beta3-adrenergic receptors--in the adipose tissues. However, since 1989, when beta3-adrenergic receptor was cloned, numerous biochemical and functional studies have confirmed its presence in various species and tissues, including the bladder and the heart. Beta3-adrenergic receptors have properties that are different from beta1 and beta2. Indeed, preclinical studies showed that the activation of the receptor Beta3 could decrease cardiac hypertrophy. 

 

In this regard, the role of beta3-adrenergic receptors in the regulation of cardiac function may be of great importance in pathological conditions.